International Human Epigenome Consortium (IHEC)
The Canadian Epigenetics Environment and Health Research Consortium (CEEHRC)

The Canadian Institutes for Health Research (CIHR) was established in 2011 as a national collaborative research funding strategy to coordinate epigenetics research in Canada. The overall goal of the Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC) is to position Canada for the rapid translation of epigenetic discoveries to improve human health.

By supporting and applying epigenetics research on a national scale, CEEHRC hopes to harness the great potential for major breakthroughs in understanding the origins of health, as well as the etiology, diagnosis, treatment and prevention of many chronic and complex diseases.

Through its Epigenomic Platform Centre program, the CEEHRC is leveraging Canada's extensive existing genomic sequencing infrastructure to develop dedicated epigenetic research capacity focused on human health and disease.

CEEHRC is supporting two Epigenomic Mapping Centres (EMCs) to generate data. Two Epigenomic Data Coordination Centres (EDCCs) have also been initiated to manage and help analyze the data.

One of the EMCs is the Multidimensional Epigenomics Mapping Centre at McGill (MEMCM) is located at MUGQIC and is led by Drs Mark Lathrop and Tomi Pastinen. Our associated EDCC is led by Dr Guillaume Bourque at MUGQIC and Dr Alan Evans at the Montreal Neurological Institute.

We are focusing on the systematic high-resolution mapping of human epigenomic markers in different cell and tissue types, and focus on three human disease areas:

  • Autoimmune and inflammatory disease, utilizing various blood cell types for analysis.
  • Cardio-metabolic disease, utilizing cardiac and skeletal muscle, liver, adipose tissue and pancreatic islets.
  • Neuropsychiatric disease, utilizing targeted brain areas in post-mortem suicide human tissue and animal models of HPA axis dysfunction.

Complimenting this approach, we are also addressing population variation in epigenomes within these areas.

Lead Investigators EMC: Dr. Tomi Pastinen and Dr. Mark Lathrop
Lead Investigators EDCC: Dr. Guillaume Bourque and Dr. Mark Lathrop
Project Manager: Dr. Tony Kwan
Tel.: (514) 398-4400 ext. 089548

Links and Contact:

IHEC: http://www.ihec-epigenomes.org/

Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC):
http://ihec-epigenomes.org/about/ihec-members/ca/
http://www.cihr-irsc.gc.ca/e/43602.html

Contact EMC:
Tomi Pastinen
Associate Professor, Canada Research Chair in Human Genomics
740 Dr. Penfield Avenue, suite 6202
Montréal, Quebec H3A 0G1
Tel: (514) 398-1777
Email: tomi.pastinen@mcgill.ca

Contact EDCC:
Guillaume Bourque
Assoc. Professor, Department of Human Genetics, McGill University
Director of Bioinformatics, McGill University & Genome Quebec Innovation Center
740 Dr Penfield Ave, Montréal (Québec) H3A 1A4, Room 6103
Tel: (514) 398-7245
Email: guil.bourque@mcgill.ca